What genetic variations affect the likelihood of developing histamine intolerance to certain foods?

This article will explore the complex yet fascinating relationship between genetics and food intolerance, especially in terms of histamine. This article will explore the research which shows the significance of this connection, offer insights that can help you start your journey towards better health and provide practical tips.

Understand genetic variations and histamine intolerance

Our genes are known to play an important role in how our body responds to food. It is especially important when it comes to histamine tolerance, whereby the body is not able to break down the compound histamine that is involved with immune responses. Inability to breakdown histamine may cause symptoms such as headaches, hives and diarrhea.

Researchers have found that certain variations of genes may increase the likelihood of developing histamine intolerance. A 2019 study in Allergy revealed that genetic polymorphisms within the gene that produces diamine oxidase - the enzyme responsible for breaking down histamine - were linked to an increased risk of intolerance.

Important Points for Getting Started

Consult a medical professional if you think you may have an intolerance to histamine. You can be guided through the testing process, which involves measuring the diamine oxidase levels in your blood.

Also, it's important to know that managing histamine sensitivity often requires dietary modifications. Histamine is found in many foods including alcohol, fermented food, and cured meats.

Genetic Factors that Affect Histamine Tolerance

More Tips and Suggestions

Keep a food journal if you are trying to control histamine intolerance. It can also help identify foods that cause your symptoms, which is particularly helpful given the unique nature of food allergies. Stress and gut health are also factors that can affect histamine in the body. Therefore, taking measures to support gut and stress management can help.


Understanding how genetic variations affect histamine intolerance is crucial to effectively managing the condition. It's not an easy issue to understand, but gaining knowledge about it can help individuals take charge of their own health. Always consult your healthcare provider if you think you may have an intolerance to histamine. Be proactive about managing the condition by making informed lifestyle and dietary decisions.